Across TCGA cell cohorts, PCYT2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCYT2-associated genes across cancer lineages are GSG1L2, GPHB5, and KCNK18. Each is linked with PCYT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYT2-to-partner and partner-to-PCYT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT2→partner) and Y-score (partner→PCYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.047	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
BLOOD_Leukemia	GHRHR →	+0.305	+3.536	<.001	.001	3	1
BLOOD_Leukemia	TCF21 →	+0.011	+3.536	<.001	.001	3	1
BLOOD_Leukemia	SEMG1 →	+0.244	+3.007	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PCYT2 survival (RNA) · tumor vs normal (RNA) · all PCYT2 data types