PCYT1B

Across TCGA patient cohorts, PCYT1B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCYT1B-associated genes across cancer lineages are FASN, ASNS, and ERK2. Each is linked with PCYT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYT1B-to-partner and partner-to-PCYT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PCYT1B-low versus PCYT1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT1B→partner) and Y-score (partner→PCYT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.323	+2.115	.016	.017	3	2
UCEC	ASNS →	+0.314	+1.247	.010	.045	3	2
SKCM	ERK2 →	+0.238	+3.321	.030	.010	3	2
UCEC	EGFR_pY1068 →	-0.171	-1.514	.045	.015	3	1
UCEC	eIF4G →	+0.218	+2.321	.039	.033	3	1
UCEC	ACC1 →	+0.430	+2.920	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FASN by PCYT1B expression — UCEC

Explore this box plot interactively →