PCYT1B

Across TCGA cell cohorts, PCYT1B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,238 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PCYT1B-associated GO terms across cancer lineages are Regulation of RNA splicing, Protein-RNA complex assembly, and Regulation of mRNA catabolic process. Each is linked with PCYT1B in more than 9 cancer types. Because this analysis shows association rather than direction, both PCYT1B-to-partner and partner-to-PCYT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by PCYT1B-low versus PCYT1B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT1B→partner) and Y-score (partner→PCYT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of RNA splicing →	+0.063	+1.116	.004	.002	3	10
SOFT_TISSUE	Protein-RNA complex assembly →	+0.048	+1.044	<.001	<.001	3	10
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.059	+1.456	<.001	<.001	3	9
BLOOD_Leukemia	Transcription initiation at RNA polymerase II promoter →	+0.046	+1.484	<.001	.001	3	9
BONE	CDP-choline pathway →	-0.180	-1.351	<.001	<.001	3	9
SKIN	Spliceosomal snRNP assembly →	+0.075	+1.014	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,238 associations by consensus.

Regulation of RNA splicing by PCYT1B expression — SOFT_TISSUE

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