PCYT1B-AS1

Across TCGA pan-cancer cohorts, PCYT1B-AS1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated PCYT1B-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PCYT1B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCYT1B-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

COAD, KIRC, and BLCA are the cancer types where PCYT1B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	III,IV	0.140	0.792	<.001	45	view →
KIRC	DFS	Tertile	III,IV	0.193	0.513	.001	42	view →
BLCA	OS	Tertile	All	1.000	0.329	.015	39	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
STAD	DFS	Tertile	All	0.529	0.741	.009	36	view →
ESCA	OS	Tertile	II,III,IV	0.105	0.867	.016	18	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	9	view →
PCPG	DFS	Tertile	All	0.229	0.822	.024	9	view →
THCA	OS	Tertile	III,IV	0.585	0.887	.006	9	view →
LIHC	DFS	Tertile	All	0.189	0.545	.036	9	view →
HNSC	DFS	Tertile	All	0.885	0.687	.029	3	view →
LUAD	OS	Tertile	All	0.606	0.814	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PCYT1B-AS1–COAD (OS)

Open the COAD breakdown →