PCTP

Across TCGA pan-cancer cohorts, PCTP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PCTP data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PCTP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCTP expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where PCTP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.870	1.000	.006	36	view →
LSCC	DFS	Median	II,III,IV	0.824	1.000	.003	23	view →
PDAC	DFS	Tertile	All	0.551	0.200	.002	15	view →
UCEC	OS	Tertile	All	1.000	0.893	.021	10	view →
LUAD	DFS	Tertile	III,IV	0.343	0.875	.011	9	view →
CCRCC	DFS	Median	II,III,IV	0.953	0.791	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PCTP–HNSC (DFS)

Open the HNSC breakdown →