PCTP

Across TCGA cell cohorts, PCTP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,109 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCTP-associated GO terms across cancer lineages are Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, Endoplasmic reticulum unfolded protein response, and Cellular response to unfolded protein. Each is linked with PCTP in more than 8 cancer types. Because this analysis shows association rather than direction, both PCTP-to-partner and partner-to-PCTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay grouped by PCTP-low versus PCTP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCTP→partner) and Y-score (partner→PCTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.123	+1.035	.004	.004	3	8
BONE	Endoplasmic reticulum unfolded protein response →	+0.107	+1.023	<.001	.001	3	8
PANCREAS	Cellular response to unfolded protein →	+0.073	+0.545	.002	.003	3	8
STOMACH	Phosphatidylcholine biosynthetic process →	+0.145	+1.614	<.001	<.001	3	8
BONE	Vesicle budding from membrane →	+0.062	+1.296	.001	<.001	2	9
BLOOD_Lymphoma	Nuclear membrane reassembly →	+0.071	+1.425	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,109 associations by consensus.

Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay by PCTP expression — LUNG_NSCLC_LUSC

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