PCTP

Across TCGA cell cohorts, PCTP mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PCTP-associated genes across cancer lineages are OR7G1 and OR2V2. Each is linked with PCTP in more than 1 cancer types. Because this analysis shows association rather than direction, both PCTP-to-partner and partner-to-PCTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7G1 grouped by PCTP-low versus PCTP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCTP→partner) and Y-score (partner→PCTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR7G1 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR2V2 →	+0.032	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR7G1 by PCTP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →