PCSK9

Across TCGA pan-cancer cohorts, PCSK9 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PCSK9’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PCSK9 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PCSK9 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where PCSK9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCSK9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.637	<.001	6	view →
LSCC	Female	All	−0.448	.002	3	view →
COAD	Male	II,III,IV	+0.636	.035	2	view →
CCRCC	Male	All	−0.281	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PCSK9–LUAD

Open the LUAD breakdown →