PCSK7

Across TCGA pan-cancer cohorts, PCSK7 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PCSK7 data layer compared with 20 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PCSK7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCSK7 expression acts as an unfavorable survival marker.

PDAC and LSCC are the cancer types where PCSK7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.279	0.723	.008	6	view →
LSCC	DFS	Quartile	All	0.486	1.000	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PCSK7–PDAC (DFS)

Open the PDAC breakdown →