PCSK7

Across TCGA patient cohorts, PCSK7 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,660 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PCSK7-associated proteins across cancer lineages are BUD13_S325, DCPS, and VPS26B. Each is linked with PCSK7 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCSK7-to-partner and partner-to-PCSK7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK7 versus BUD13_S325 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK7→partner) and Y-score (partner→PCSK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BUD13_S325 →	+0.345	+0.563	<.001	<.001	3	4
HNSC	DCPS →	+0.296	+0.460	<.001	<.001	3	4
BRCA	VPS26B →	+0.209	+0.474	.001	<.001	3	4
GBM	PYGL →	-0.415	-0.191	.005	.007	3	4
HNSC	SHANK2_S67 →	-1.293	-0.553	.001	<.001	3	3
HNSC	SPTBN1_S2128 →	+0.437	+0.499	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,660 associations by consensus.

PCSK7 vs BUD13_S325 — HNSC

Explore this scatter interactively →