PCSK7

Across TCGA patient cohorts, PCSK7 mutation is significantly associated with the RNA expression of many other genes, with 1,518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK7-associated genes across cancer lineages are EXOSC9, GTF2A2, and AP1S3. Each is linked with PCSK7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK7-to-partner and partner-to-PCSK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by PCSK7-low versus PCSK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK7→partner) and Y-score (partner→PCSK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXOSC9 →	+0.427	+2.439	.001	.001	3	3
UCEC	GTF2A2 →	+0.422	+3.754	.001	<.001	3	3
UCEC	AP1S3 →	+0.449	+2.194	.002	.001	3	3
UCEC	DNAJC28 →	+0.276	+2.233	.004	.001	3	3
UCEC	HACD3 →	+0.471	+1.942	.008	.002	3	3
LIHC	RNU1-19P →	+0.167	+5.902	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,518 associations by consensus.

EXOSC9 by PCSK7 expression — UCEC

Explore this box plot interactively →