PCSK7

Across TCGA patient cohorts, PCSK7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK7-associated genes across cancer lineages are eIF4E, GSK-3a-b_pS21_S9, and P-Cadherin. Each is linked with PCSK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK7-to-partner and partner-to-PCSK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PCSK7-low versus PCSK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK7→partner) and Y-score (partner→PCSK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.157	+2.335	.032	.018	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.536	+2.070	<.001	.001	3	2
UCEC	P-Cadherin →	-0.149	-2.807	.002	.002	3	2
UCEC	ATM →	-0.559	-3.000	<.001	<.001	3	2
UCEC	Bim →	-0.200	-1.736	.028	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.429	+1.720	.037	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by PCSK7 expression — UCEC

Explore this box plot interactively →