PCSK7

Across TCGA cell cohorts, PCSK7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,921 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCSK7-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Cytosolic transport, and Vacuolar transport. Each is linked with PCSK7 in more than 14 cancer types. Because this analysis shows association rather than direction, both PCSK7-to-partner and partner-to-PCSK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by PCSK7-low versus PCSK7-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK7→partner) and Y-score (partner→PCSK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Pre-mRNA catabolic process →	+0.120	+0.703	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.088	+1.494	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.057	+1.115	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to vacuole →	+0.089	+1.432	<.001	<.001	3	14
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.100	+1.391	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.151	+1.355	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,921 associations by consensus.

Pre-mRNA catabolic process by PCSK7 expression — SKIN

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