PCSK6

Across TCGA cell cohorts, PCSK6 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCSK6-associated genes across cancer lineages are ADAM30, USP29, and OR4D5. Each is linked with PCSK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK6-to-partner and partner-to-PCSK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM30 grouped by PCSK6-low versus PCSK6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK6→partner) and Y-score (partner→PCSK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	2
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4N4 →	+0.277	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RTP2 →	+0.030	+4.371	.006	.005	3	1
LUNG_NSCLC_LUAD	C16orf82 →	+0.009	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

ADAM30 by PCSK6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →