PCSK6

Across TCGA cell cohorts, PCSK6 mutation is significantly associated with the mutation status of many other genes, with 4,642 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCSK6-associated genes across cancer lineages are ITGAX, ARMC5, and PIK3R5. Each is linked with PCSK6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCSK6-to-partner and partner-to-PCSK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAX grouped by PCSK6-low versus PCSK6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK6→partner) and Y-score (partner→PCSK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAX →	+2.632	+2.632	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	ARMC5 →	+5.392	+5.392	.004	.004	1	4
SKIN	PIK3R5 →	+3.638	+4.117	.002	.002	1	4
SKIN	ST6GAL2 →	+2.830	+3.548	.009	.009	1	4
LARGE_INTESTINE	ABCA12 →	+1.462	+2.823	.003	.003	1	4
LARGE_INTESTINE	DOCK3 →	+1.725	+3.091	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,642 associations by consensus.

ITGAX by PCSK6 expression — LARGE_INTESTINE

Explore this box plot interactively →