PCSK5

Across TCGA patient cohorts, PCSK5 protein abundance is significantly associated with the RNA expression of many other genes, with 6,692 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCSK5-associated genes across cancer lineages are LOXL2, COL1A1, and CRYAB. Each is linked with PCSK5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCSK5-to-partner and partner-to-PCSK5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK5 versus LOXL2 in BRCA, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK5→partner) and Y-score (partner→PCSK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOXL2 →	+1.261	+1.080	.001	.008	3	5
BRCA	COL1A1 →	+1.626	+1.373	<.001	<.001	3	4
LSCC	CRYAB →	+1.302	+0.443	<.001	<.001	3	4
UCEC	FN1 →	+1.039	+0.649	.008	.005	3	4
UCEC	FBLN5 →	+0.954	+0.762	<.001	<.001	3	4
GBM	COL6A3 →	+1.438	+0.435	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,692 associations by consensus.

PCSK5 vs LOXL2 — BRCA

Explore this scatter interactively →