PCSK5

Across TCGA patient cohorts, PCSK5 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK5-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and RAD51. Each is linked with PCSK5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCSK5-to-partner and partner-to-PCSK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PCSK5-low versus PCSK5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK5→partner) and Y-score (partner→PCSK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.226	+3.338	<.001	.004	3	4
COAD	INPP4B →	-0.330	-1.991	.029	.031	3	3
COAD	RAD51 →	+0.226	+3.169	<.001	.017	3	3
UCEC	STAT3_pY705 →	-0.348	-1.754	<.001	<.001	3	3
UCEC	eIF4E →	+0.131	+1.415	.022	.002	3	3
UCEC	FoxM1 →	+0.174	+1.662	.013	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Caspase-7-cleavedD198 by PCSK5 expression — COAD

Explore this box plot interactively →