PCSK5

Across TCGA cell cohorts, PCSK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,663 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCSK5-associated GO terms across cancer lineages are Negative regulation of low-density lipoprotein particle receptor catabolic process, Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure, and Negative regulation of receptor catabolic process. Each is linked with PCSK5 in more than 16 cancer types. Because this analysis shows association rather than direction, both PCSK5-to-partner and partner-to-PCSK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of low-density lipoprotein particle receptor catabolic process grouped by PCSK5-low versus PCSK5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK5→partner) and Y-score (partner→PCSK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of low-density lipoprotein particle receptor catabolic process →	-0.315	-2.386	<.001	<.001	3	17
KIDNEY	Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure →	+1.448	+2.880	<.001	<.001	3	15
STOMACH	Negative regulation of receptor catabolic process →	-0.190	-2.212	.001	<.001	3	13
BONE	Renal system process involved in regulation of systemic arterial blood pressure →	+1.459	+1.918	<.001	<.001	3	11
BLOOD_Myeloma	Cytokine precursor processing →	-0.213	-0.968	.002	<.001	2	10
BLOOD_Myeloma	Cellular response to amyloid-beta →	+0.090	+0.984	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,663 associations by consensus.

Negative regulation of low-density lipoprotein particle receptor catabolic process by PCSK5 expression — STOMACH

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