PCSK5

Across TCGA cell cohorts, PCSK5 mutation is significantly associated with the RNA expression of many other genes, with 1,440 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCSK5-associated genes across cancer lineages are METTL4, GPR3, and POTEB3. Each is linked with PCSK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK5-to-partner and partner-to-PCSK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by PCSK5-low versus PCSK5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK5→partner) and Y-score (partner→PCSK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	METTL4 →	+0.601	+2.614	<.001	.003	3	3
LARGE_INTESTINE	GPR3 →	+0.739	+2.628	<.001	<.001	3	3
URINARY_TRACT	POTEB3 →	+0.011	+4.217	.002	.005	3	2
BLOOD_Leukemia	SEPTIN3 →	+1.170	+2.614	.001	.003	3	2
BLOOD_Leukemia	CEP128 →	+0.952	+2.674	<.001	.003	3	2
LARGE_INTESTINE	TTC33 →	+0.618	+2.130	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,440 associations by consensus.

METTL4 by PCSK5 expression — BLOOD_Leukemia

Explore this box plot interactively →