PCSK4

Across TCGA patient cohorts, PCSK4 mutation is significantly associated with the RNA expression of many other genes, with 2,411 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK4-associated genes across cancer lineages are LARP1B, FUT10, and RNU6-649P. Each is linked with PCSK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK4-to-partner and partner-to-PCSK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1B grouped by PCSK4-low versus PCSK4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK4→partner) and Y-score (partner→PCSK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LARP1B →	+0.542	+3.584	.002	.002	3	3
COAD	FUT10 →	+0.536	+3.598	.001	.001	3	3
LGG	RNU6-649P →	+0.378	+7.977	<.001	.007	3	3
STAD	TVP23B →	+0.564	+3.338	.002	.005	3	3
STAD	MIR7-3 →	+0.263	+2.553	.003	.006	3	3
UCEC	MIR4672 →	+0.316	+1.848	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,411 associations by consensus.

LARP1B by PCSK4 expression — COAD

Explore this box plot interactively →