PCOLCE2

Across TCGA patient cohorts, PCOLCE2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCOLCE2-associated genes across cancer lineages are IRS1, Gab2, and p38-MAPK_pT180_Y182. Each is linked with PCOLCE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCOLCE2-to-partner and partner-to-PCOLCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by PCOLCE2-low versus PCOLCE2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE2→partner) and Y-score (partner→PCOLCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IRS1 →	+0.185	+3.321	.006	.009	3	3
UCEC	Gab2 →	+0.368	+3.169	.012	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.426	-1.794	.021	.027	3	2
UCEC	Cyclin-B1 →	+0.739	+3.459	.001	.005	3	2
SKCM	N-Cadherin →	+0.214	+3.169	.014	.018	3	2
LUAD	Caspase-3 →	+0.230	+2.820	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

IRS1 by PCOLCE2 expression — SKCM

Explore this box plot interactively →