PCOLCE2

Across TCGA cell cohorts, PCOLCE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,026 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PCOLCE2-associated GO terms across cancer lineages are Positive regulation of JNK cascade, Protein localization to nucleolus, and Maturation of SSU-rRNA. Each is linked with PCOLCE2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PCOLCE2-to-partner and partner-to-PCOLCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of JNK cascade grouped by PCOLCE2-low versus PCOLCE2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE2→partner) and Y-score (partner→PCOLCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of JNK cascade →	-0.050	-1.742	.001	.009	3	11
BREAST	Protein localization to nucleolus →	+0.146	+2.533	<.001	<.001	3	10
LUNG_SCLC	Maturation of SSU-rRNA →	+0.084	+1.997	.007	.002	3	10
LUNG_NSCLC_LUSC	DNA-templated transcription termination →	+0.103	+2.214	.005	.007	2	11
URINARY_TRACT	IMP biosynthetic process →	+0.191	+2.236	<.001	<.001	3	10
PANCREAS	rRNA metabolic process →	+0.093	+1.344	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

Positive regulation of JNK cascade by PCOLCE2 expression — LUNG_SCLC

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