PCOLCE2

Across TCGA cell cohorts, PCOLCE2 mutation is significantly associated with the drug of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCOLCE2-associated genes across cancer lineages are CP466722, 123829, and WYE-125132. Each is linked with PCOLCE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCOLCE2-to-partner and partner-to-PCOLCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CP466722 grouped by PCOLCE2-low versus PCOLCE2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE2→partner) and Y-score (partner→PCOLCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CP466722 →	+0.395	+2.652	.046	.045	3	1
LARGE_INTESTINE	123829 →	+0.593	+2.871	.031	.021	3	1
LARGE_INTESTINE	WYE-125132 →	+0.545	+2.652	.033	.045	3	1
LARGE_INTESTINE	ZSTK474 →	+0.549	+2.786	.036	.037	2	1
LARGE_INTESTINE	CX-5461 →	+0.644	+2.652	.029	.045	2	1
LARGE_INTESTINE	Linsitinib →	-0.478	-2.745	.029	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CP466722 by PCOLCE2 expression — LARGE_INTESTINE

Explore this box plot interactively →