PCNX4

Across TCGA cell cohorts, PCNX4 mutation is significantly associated with the RNA expression of many other genes, with 792 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCNX4-associated genes across cancer lineages are SEMG2, OR2T12, and CRYBB3. Each is linked with PCNX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCNX4-to-partner and partner-to-PCNX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by PCNX4-low versus PCNX4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX4→partner) and Y-score (partner→PCNX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SEMG2 →	+0.031	+4.269	.002	.005	3	2
CNS	OR2T12 →	+0.071	+3.700	<.001	.003	3	1
BLOOD_Leukemia	CRYBB3 →	+0.068	+3.567	.001	.003	3	1
BLOOD_Leukemia	CGB2 →	+0.728	+3.234	<.001	.008	3	1
BLOOD_Leukemia	SULT2A1 →	+0.074	+3.339	.006	.006	3	1
BLOOD_Leukemia	FGF21 →	+0.233	+3.864	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 792 associations by consensus.

SEMG2 by PCNX4 expression — LUNG_SCLC

Explore this box plot interactively →