PCNX2

Across TCGA patient cohorts, PCNX2 mutation is significantly associated with the RNA expression of many other genes, with 5,319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNX2-associated genes across cancer lineages are BUB1B, UQCRC1, and NUSAP1. Each is linked with PCNX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCNX2-to-partner and partner-to-PCNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB1B grouped by PCNX2-low versus PCNX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX2→partner) and Y-score (partner→PCNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB1B →	+0.414	+1.245	.005	.002	3	5
UCEC	UQCRC1 →	+0.297	+1.201	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.546	+1.243	<.001	<.001	3	5
COAD	SATB1-AS1 →	-0.356	-3.633	.006	.001	3	4
COAD	PTMAP4 →	+1.309	+1.952	<.001	.002	3	4
COAD	CDC7 →	+0.504	+2.321	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,319 associations by consensus.

BUB1B by PCNX2 expression — UCEC

Explore this box plot interactively →