PCNX2

Across TCGA patient cohorts, PCNX2 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNX2-associated genes across cancer lineages are ASNS, c-Kit, and EGFR_pY1068. Each is linked with PCNX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCNX2-to-partner and partner-to-PCNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PCNX2-low versus PCNX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX2→partner) and Y-score (partner→PCNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.468	+2.178	<.001	.001	3	4
STAD	c-Kit →	-0.310	-2.321	.015	.032	3	3
UCEC	EGFR_pY1068 →	-0.177	-0.959	.004	.018	3	3
UCEC	IGFBP2 →	-0.547	-1.295	<.001	.008	3	3
COAD	mTOR_pS2448 →	-0.154	-2.446	.011	.018	2	4
UCEC	STAT3_pY705 →	-0.270	-1.530	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

ASNS by PCNX2 expression — COAD

Explore this box plot interactively →