PCNX2

Across TCGA cell cohorts, PCNX2 mutation is significantly associated with the RNA expression of many other genes, with 715 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCNX2-associated genes across cancer lineages are USP17L15, TLE6, and CUEDC2. Each is linked with PCNX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCNX2-to-partner and partner-to-PCNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L15 grouped by PCNX2-low versus PCNX2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX2→partner) and Y-score (partner→PCNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	USP17L15 →	+0.017	+4.000	.001	.008	3	2
LARGE_INTESTINE	TLE6 →	+0.833	+2.584	.001	.002	3	2
LARGE_INTESTINE	CUEDC2 →	+0.657	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	SYNGR2 →	-0.767	-2.520	<.001	.003	3	2
LARGE_INTESTINE	PMP22 →	+1.296	+2.459	.001	.006	3	2
LARGE_INTESTINE	HDDC2 →	+0.550	+3.321	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 715 associations by consensus.

USP17L15 by PCNX2 expression — BONE

Explore this box plot interactively →