PCNX1

Across TCGA patient cohorts, PCNX1 mutation is significantly associated with the RNA expression of many other genes, with 5,940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNX1-associated genes across cancer lineages are EIF2S1, BUB3, and CCDC43. Each is linked with PCNX1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCNX1-to-partner and partner-to-PCNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2S1 grouped by PCNX1-low versus PCNX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX1→partner) and Y-score (partner→PCNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF2S1 →	+0.569	+3.196	<.001	.009	3	6
UCEC	BUB3 →	+0.380	+1.911	<.001	<.001	3	6
UCEC	CCDC43 →	+0.482	+2.102	<.001	<.001	3	5
BLCA	ERI2 →	+0.707	+3.372	<.001	.005	3	5
LUAD	MCMBP →	+0.379	+2.473	.001	.001	3	5
UCEC	DNAJC9 →	+0.470	+1.462	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,940 associations by consensus.

EIF2S1 by PCNX1 expression — COAD

Explore this box plot interactively →