PCNX1

Across TCGA patient cohorts, PCNX1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNX1-associated genes across cancer lineages are PCNA, Caveolin-1, and MEK1. Each is linked with PCNX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCNX1-to-partner and partner-to-PCNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PCNX1-low versus PCNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNX1→partner) and Y-score (partner→PCNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.192	+2.662	.001	<.001	3	5
LUAD	Caveolin-1 →	-0.688	-3.000	.039	.035	2	5
UCEC	MEK1 →	+0.357	+2.736	<.001	<.001	3	4
UCEC	PDCD4 →	-0.425	-1.369	.001	.003	3	4
UCEC	ATM →	-0.469	-1.986	<.001	.002	3	4
STAD	Annexin_VII →	-0.185	-3.169	.016	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

PCNA by PCNX1 expression — UCEC

Explore this box plot interactively →