PCNT

Across TCGA patient cohorts, PCNT mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNT-associated genes across cancer lineages are FASN, ATM, and PCNA. Each is linked with PCNT in more than 3 cancer types. Because this analysis shows association rather than direction, both PCNT-to-partner and partner-to-PCNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PCNT-low versus PCNT-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNT→partner) and Y-score (partner→PCNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.360	+3.337	.023	.004	3	4
UCEC	ATM →	-0.513	-1.652	<.001	<.001	3	4
UCEC	PCNA →	+0.185	+1.152	<.001	.002	3	4
UCEC	4E-BP1 →	+0.313	+3.058	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.585	+1.652	<.001	<.001	3	3
COAD	EGFR_pY1068 →	-0.230	-2.000	.022	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

FASN by PCNT expression — STAD

Explore this box plot interactively →