PCNT

Across TCGA cell cohorts, PCNT mutation is significantly associated with the RNA expression of many other genes, with 1,759 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCNT-associated genes across cancer lineages are TTC33, BBS7, and PPM1M. Each is linked with PCNT in more than 3 cancer types. Because this analysis shows association rather than direction, both PCNT-to-partner and partner-to-PCNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC33 grouped by PCNT-low versus PCNT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNT→partner) and Y-score (partner→PCNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTC33 →	+0.593	+3.584	<.001	<.001	3	4
LARGE_INTESTINE	BBS7 →	+0.572	+1.808	<.001	.001	3	4
LARGE_INTESTINE	PPM1M →	+0.765	+1.808	<.001	.001	3	4
LARGE_INTESTINE	XYLB →	+0.614	+2.000	.001	.009	3	4
LARGE_INTESTINE	PDE6C →	+0.209	+2.068	<.001	<.001	3	3
LARGE_INTESTINE	TNRC6B →	+0.682	+2.386	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,759 associations by consensus.

TTC33 by PCNT expression — LARGE_INTESTINE

Explore this box plot interactively →