PCNP

Across TCGA pan-cancer cohorts, PCNP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PCNP data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PCNP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCNP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where PCNP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.906	1.000	.006	49	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	13	view →
LSCC	OS	Median	II,III,IV	0.924	0.801	.037	13	view →
LUAD	OS	Tertile	III,IV	1.000	0.208	.007	10	view →
OV	DFS	Tertile	All	0.942	0.665	.035	8	view →
GBM	DFS	Median	All	0.666	0.818	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PCNP–HNSC (DFS)

Open the HNSC breakdown →