PCNA

Across TCGA pan-cancer cohorts, PCNA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PCNA data layer compared with 29 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PCNA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCNA expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where PCNA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.911	1.000	.012	42	view →
CCRCC	OS	Tertile	All	0.561	1.000	.003	32	view →
PDAC	OS	Tertile	III,IV	0.293	0.570	.015	15	view →
LSCC	OS	Quartile	II,III,IV	0.929	0.484	.007	12	view →
HNSC	DFS	Median	All	0.698	1.000	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PCNA–COAD (DFS)

Open the COAD breakdown →