Across TCGA patient cohorts, PCMTD2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCMTD2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with PCMTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCMTD2-to-partner and partner-to-PCMTD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCMTD2→partner) and Y-score (partner→PCMTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.349	-2.115	.001	.019	3	1
UCEC	eIF4E →	+0.206	+2.820	.025	.035	3	1
UCEC	A-Raf_pS299 →	-0.148	-3.169	.004	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.639	+2.115	.003	.019	3	1
UCEC	INPP4B →	-0.299	-2.102	.034	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.207	-2.102	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

PCMTD2 survival (RNA) · tumor vs normal (RNA) · all PCMTD2 data types