PCMT1

Across TCGA patient cohorts, PCMT1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCMT1-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and EGFR_pY1068. Each is linked with PCMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCMT1-to-partner and partner-to-PCMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PCMT1-low versus PCMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCMT1→partner) and Y-score (partner→PCMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.810	+3.341	.001	.005	3	2
UCEC	eEF2 →	+0.476	+3.321	.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.233	-2.459	.028	.019	3	1
UCEC	Heregulin →	-0.128	-2.321	.014	.034	3	1
UCEC	mTOR_pS2448 →	-0.142	-2.439	.025	.019	3	1
UCEC	PCNA →	+0.204	+2.222	.026	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by PCMT1 expression — UCEC

Explore this box plot interactively →