PCLAF

Across TCGA patient cohorts, PCLAF mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCLAF-associated genes across cancer lineages are OR5M9, IFNA2, and FAT1P1. Each is linked with PCLAF in more than 1 cancer types. Because this analysis shows association rather than direction, both PCLAF-to-partner and partner-to-PCLAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M9 grouped by PCLAF-low versus PCLAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLAF→partner) and Y-score (partner→PCLAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR5M9 →	+0.089	+4.621	.003	.008	3	2
BLCA	IFNA2 →	+0.058	+5.788	.002	.003	3	2
HNSC	FAT1P1 →	+0.078	+5.124	<.001	.008	3	2
UCEC	FCF1P10 →	+0.352	+4.621	<.001	.008	3	2
HNSC	RNU6-603P →	+0.499	+5.505	<.001	.004	3	2
UCEC	SNORA41B →	+1.146	+6.049	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

OR5M9 by PCLAF expression — UCEC

Explore this box plot interactively →