PCLAF

Across TCGA patient cohorts, PCLAF mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCLAF-associated genes across cancer lineages are Monocytes, CD4+ memory T-cells, and CD4+ T-cells. Each is linked with PCLAF in more than 1 cancer types. Because this analysis shows association rather than direction, both PCLAF-to-partner and partner-to-PCLAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by PCLAF-low versus PCLAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLAF→partner) and Y-score (partner→PCLAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Monocytes →	+0.019	+5.475	<.001	.029	3	1
UCEC	CD4+ memory T-cells →	+0.049	+3.202	.001	.047	3	1
UCEC	CD4+ T-cells →	+0.015	+6.481	<.001	.014	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Monocytes by PCLAF expression — UCEC

Explore this box plot interactively →