PCLAF

Across TCGA cell cohorts, PCLAF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,313 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PCLAF-associated GO terms across cancer lineages are Dihydrofolate metabolic process, Meiotic chromosome segregation, and DNA replication initiation. Each is linked with PCLAF in more than 18 cancer types. Because this analysis shows association rather than direction, both PCLAF-to-partner and partner-to-PCLAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dihydrofolate metabolic process grouped by PCLAF-low versus PCLAF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLAF→partner) and Y-score (partner→PCLAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Dihydrofolate metabolic process →	+0.215	+1.821	.001	.002	3	19
OESOPHAGUS	Meiotic chromosome segregation →	+0.166	+1.780	<.001	.001	3	19
PANCREAS	DNA replication initiation →	+0.199	+1.762	<.001	<.001	3	19
BLOOD_Myeloma	Meiotic cell cycle →	+0.087	+2.321	.001	<.001	3	19
PANCREAS	DNA replication →	+0.111	+1.533	<.001	<.001	3	19
PANCREAS	DNA replication checkpoint signaling →	+0.171	+1.609	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,313 associations by consensus.

Dihydrofolate metabolic process by PCLAF expression — OESOPHAGUS

Explore this box plot interactively →