PCK1

Across TCGA pan-cancer cohorts, PCK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PCK1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PCK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PCK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, HNSC, and COAD are the cancer types where PCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.901	0.549	<.001	53	view →
HNSC	DFS	Quartile	III,IV	0.590	1.000	<.001	23	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.910	.040	12	view →
PDAC	DFS	Quartile	II,III,IV	0.607	0.222	.005	12	view →
LUAD	DFS	Tertile	All	0.572	0.792	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PCK1–CCRCC (DFS)

Open the CCRCC breakdown →