PCK1

Across TCGA patient cohorts, PCK1 mutation is significantly associated with the RNA expression of many other genes, with 3,468 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCK1-associated genes across cancer lineages are KIAA1841, CX3CR1, and ZNF77. Each is linked with PCK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCK1-to-partner and partner-to-PCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1841 grouped by PCK1-low versus PCK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK1→partner) and Y-score (partner→PCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIAA1841 →	+0.459	+2.243	<.001	.001	3	3
UCEC	CX3CR1 →	-0.421	-1.999	.005	.002	3	3
LUAD	ZNF77 →	+0.543	+2.830	<.001	.001	3	3
UCEC	CDC45 →	+0.484	+1.527	.007	.004	3	3
READ	ATP6V1E1P2 →	+0.442	+5.039	<.001	.008	3	3
UCEC	ZWINT →	+0.576	+1.947	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,468 associations by consensus.

KIAA1841 by PCK1 expression — UCEC

Explore this box plot interactively →