PCK1

Across TCGA patient cohorts, PCK1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCK1-associated genes across cancer lineages are IRS1, NDRG1_pT346, and p38-MAPK_pT180_Y182. Each is linked with PCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCK1-to-partner and partner-to-PCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by PCK1-low versus PCK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK1→partner) and Y-score (partner→PCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IRS1 →	+0.174	+2.476	.003	.009	3	2
SKCM	NDRG1_pT346 →	-0.533	-3.169	.038	.018	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.368	-1.861	.014	.002	3	2
UCEC	ERK2 →	+0.187	+1.321	.003	.029	3	2
UCEC	MSH2 →	-0.367	-3.143	<.001	<.001	3	2
UCEC	MSH6 →	-0.404	-3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

IRS1 by PCK1 expression — SKCM

Explore this box plot interactively →