PCK1

Across TCGA cell cohorts, PCK1 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCK1-associated genes across cancer lineages are C12orf40, SLC22A9, and SOHLH1. Each is linked with PCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCK1-to-partner and partner-to-PCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by PCK1-low versus PCK1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK1→partner) and Y-score (partner→PCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.016	+4.029	<.001	.009	3	2
KIDNEY	SLC22A9 →	+0.017	+4.491	<.001	.002	3	1
KIDNEY	SOHLH1 →	+0.018	+4.121	<.001	.006	3	1
KIDNEY	TCP10L2 →	+0.062	+4.954	<.001	<.001	3	1
KIDNEY	LIPF →	+0.022	+4.121	.001	.006	3	1
KIDNEY	GAGE12H →	+0.532	+4.954	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

C12orf40 by PCK1 expression — OVARY

Explore this box plot interactively →