PCIF1

Across TCGA pan-cancer cohorts, PCIF1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PCIF1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PCIF1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PCIF1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where PCIF1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCIF1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.458	.006	6	view →
LUAD	Female	II,III,IV	−0.226	<.001	6	view →
HNSC	Male	II,III,IV	+0.129	<.001	5	view →
CCRCC	Male	All	+0.110	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PCIF1–COAD

Open the COAD breakdown →