PCIF1

Across TCGA patient cohorts, PCIF1 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCIF1-associated genes across cancer lineages are Th2 cells, Erythrocytes, and GMP. Each is linked with PCIF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCIF1-to-partner and partner-to-PCIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by PCIF1-low versus PCIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCIF1→partner) and Y-score (partner→PCIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Th2 cells →	+0.151	+2.010	.013	.017	3	3
STAD	Erythrocytes →	+0.026	+3.164	<.001	.032	3	2
STAD	GMP →	+0.133	+2.584	<.001	.036	3	2
STAD	Osteoblast →	+0.022	+2.669	.009	.035	3	2
LUSC	Mesangial cells →	+0.027	+3.302	.015	.025	3	1
UCEC	Class-switched memory B-cells →	-0.042	-2.137	.029	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Th2 cells by PCIF1 expression — UCEC

Explore this box plot interactively →