PCIF1

Across TCGA cell cohorts, PCIF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,702 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCIF1-associated GO terms across cancer lineages are Regulation of centriole-centriole cohesion, Positive regulation of attachment of spindle microtubules to kinetochore, and Regulation of protein sumoylation. Each is linked with PCIF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PCIF1-to-partner and partner-to-PCIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole-centriole cohesion grouped by PCIF1-low versus PCIF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCIF1→partner) and Y-score (partner→PCIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of centriole-centriole cohesion →	+0.180	+0.625	.004	<.001	2	13
SOFT_TISSUE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.138	+0.464	<.001	<.001	3	12
BONE	Regulation of protein sumoylation →	+0.093	+0.538	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.081	+0.802	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Mitotic centrosome separation →	+0.107	+0.662	.004	.004	3	11
BONE	DNA strand elongation involved in DNA replication →	+0.195	+0.599	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,702 associations by consensus.

Regulation of centriole-centriole cohesion by PCIF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →