PCIF1

Across TCGA cell cohorts, PCIF1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PCIF1-associated genes across cancer lineages are CDH9, ARL5C, and RIT2. Each is linked with PCIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCIF1-to-partner and partner-to-PCIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH9 grouped by PCIF1-low versus PCIF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCIF1→partner) and Y-score (partner→PCIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDH9 →	+0.277	+3.347	<.001	.005	3	1
SKIN	ARL5C →	+0.092	+3.906	<.001	.002	3	1
SKIN	RIT2 →	+0.020	+4.022	<.001	.006	3	1
SKIN	TEKT1 →	+0.044	+3.345	.009	.007	3	1
SKIN	CT83 →	+1.032	+3.453	.005	.009	3	1
SKIN	LY6G6D →	+0.127	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CDH9 by PCIF1 expression — SKIN

Explore this box plot interactively →