PCGF6

Across TCGA pan-cancer cohorts, PCGF6 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PCGF6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PCGF6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PCGF6 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where PCGF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCGF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.488	<.001	9	view →
LSCC	Female	All	+0.311	<.001	8	view →
CCRCC	All	All	+0.343	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PCGF6–LUAD

Open the LUAD breakdown →