PCGF6

Across TCGA patient cohorts, PCGF6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCGF6-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with PCGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF6-to-partner and partner-to-PCGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PCGF6-low versus PCGF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF6→partner) and Y-score (partner→PCGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-2.973	.017	.035	3	1
UCEC	eEF2 →	+0.369	+2.999	.026	.035	3	1
UCEC	EGFR_pY1068 →	-0.315	-3.321	.007	.010	3	1
UCEC	A-Raf_pS299 →	-0.175	-2.459	.001	.019	3	1
UCEC	GATA6 →	-0.158	-2.314	.042	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.205	-2.571	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

14-3-3_beta by PCGF6 expression — UCEC

Explore this box plot interactively →