PCGF6

Across TCGA cell cohorts, PCGF6 mutation is significantly associated with the mutation status of many other genes, with 2,901 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCGF6-associated genes across cancer lineages are SYNJ2, MYH7B, and TRPM3. Each is linked with PCGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF6-to-partner and partner-to-PCGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNJ2 grouped by PCGF6-low versus PCGF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF6→partner) and Y-score (partner→PCGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SYNJ2 →	+1.807	+2.584	.005	.005	1	2
LARGE_INTESTINE	MYH7B →	+2.155	+3.392	<.001	<.001	1	2
CNS	TRPM3 →	+3.614	+4.954	.001	.001	1	2
CNS	MYO1E →	+4.614	+4.614	.006	.006	1	2
CNS	RADIL →	+4.199	+5.347	<.001	<.001	1	2
CNS	VWA5B1 →	+4.614	+4.614	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,901 associations by consensus.

SYNJ2 by PCGF6 expression — LARGE_INTESTINE

Explore this box plot interactively →