PCGF5

Across TCGA patient cohorts, PCGF5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCGF5-associated genes across cancer lineages are Gab2, 14-3-3_beta, and EGFR_pY1068. Each is linked with PCGF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF5-to-partner and partner-to-PCGF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PCGF5-low versus PCGF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF5→partner) and Y-score (partner→PCGF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.341	+1.906	.003	.015	3	2
UCEC	14-3-3_beta →	-0.079	-1.673	.017	.040	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.999	.002	<.001	3	1
UCEC	eIF4E →	+0.191	+1.938	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.133	-1.938	<.001	.001	3	1
UCEC	ERK2 →	+0.162	+1.678	.010	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Gab2 by PCGF5 expression — UCEC

Explore this box plot interactively →